![]() (00)00470-Xīlanco M (2001) Cellular localization of orexin receptors in human pituitary. īingham S, Davey PT, Babbs AJ et al (2001) Orexin-A, an hypothalamic peptide with analgesic properties. Neuroscience 199:153–165īhagwandin A, Gravett N, Bennett NC, Manger PR (2013) Distribution of parvalbumin, calbindin and calretinin containing neurons and terminal networks in relation to sleep associated nuclei in the brain of the giant Zambian mole-rat (Fukomys mechowii). īhagwandin A, Gravett N, Hemingway J et al (2011b) Orexinergic neuron numbers in three species of African mole rats with rhythmic and arrhythmic chronotypes. īhagwandin A, Fuxe K, Bennett NC, Manger PR (2011a) Distribution of orexinergic neurons and their terminal networks in the brains of two species of African mole rats. īeuckmann CT, Yanagisawa M (2002) Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. īaumann CR, Clark EL, Pedersen NP et al (2008) Do enteric neurons make hypocretin? Regul Pept 147:1–3. 9:1061īarb CR, Matteri RL (2005) Orexin-B modulates luteinizing hormone and growth hormone secretion from porcine pituitary cells in culture. Īzeez IA, Del Gallo F, Cristino L, Bentivoglio M (2018) Daily fluctuation of orexin neuron activity and wiring: The challenge of "chronoconnectivity. PhD Thesis published by the University of Verona IRIS Catalogue. Īzeez IA (2018) The oscillating lateral hypothalamus and the orexinergic system. Īston-Jones G, Smith RJ, Moorman DE, Richardson KA (2009) Role of lateral hypothalamic orexin neurons in reward processing and addiction. (02)00195-7Īmiya N, Amano M, Oka Y et al (2007) Immunohistochemical localization of orexin/hypocretin-like immunoreactive peptides and melanin-concentrating hormone in the brain and pituitary of medada. Īlvarez CE, Sutcliffe JG (2002) Hypocretin is an early member of the incretin gene family. Mol Phylogenet Evol 48:964–985Īlexandre C, Andermann ML, Scammell TE (2013) Control of arousal by the orexin neurons. Īgnarsson I, May-Collado LJ (2008) The phylogeny of Cetartiodactyla: the importance of dense taxon sampling, missing data, and the remarkable promise of cytochrome b to provide reliable specieslevel phylogenies. ![]() The presence of the neuropeptide in the cerebrospinal fluid and peripheral tissues, as well as its alteration in different animal models and conditions are also reviewed.Ībounoori M, Maddah MM, Akbari E et al (2020) The effect of orexin receptor antagonism on quinpirole-induced compulsive-like checking behavior in rats. Hence, this review highlights the distinct variabilities in the morphophysiological aspects of the orexinergic system in the vertebrate animals, mammals and non-mammals, its presence in other brain-related structures, including its involvement in ageing and neurodegenerative diseases. From the documentations, variations exist in the neuroanatomical profile of the orexinergic neuron soma, fibres and their receptors from animal to animal. In the last two decades, the orexinergic system has been a topic of great interest to the scientific community with many reports in the public domain. The broad range of functions regulated by the orexinergic system has led to its description as ‘’physiological integrator’’. The hypothalamic neurons containing the orexin neuropeptides have been implicated in diverse functions, especially related to the control of a variety of homeostatic functions including feeding behaviour, arousal, wakefulness stability and energy expenditure. The extensive networks of orexin axonal fibres and their terminals allow these neuropeptidergic neurons to exert great influence on their target regions. Generally, the term ‘’orexinergic system’’ usually refers to the orexin peptides and their receptors, as well as to the orexin neurons and their projections to different parts of the central nervous system. From the lateral hypothalamus, the orexin-containing neurons project their fibres extensively to other brain structures, and the spinal cord constituting the central orexinergic system. Orexin (hypocretin), is a neuropeptide produced by a subset of neurons in the lateral hypothalamus.
0 Comments
Leave a Reply. |